Author Archives: Alex

Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

June 2019 Authors: De Coster Wouter, De Rijk Peter, De Roeck Arne, De Pooter Tim, D’Hert Svenn, Strazisar Mojca, Kristel Sleegers and Van Broeckhoven Christine Info: Researchers from VIB Center for Molecular Neurology, Antwerp Belgium and University of Antwerp assess … more »

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function

May 2019 Authors: John A. Kubi, Andy C.H. Chen, Sze Wan Fong, Keng Po Lai, Chris K.C. Wong, William S.B. Yeung, Kai Fai Lee, Yin Lau Lee Info: From the University of Hong Kong and Hong Kong Baptist University, this … more »

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Sage Science Receives $1.8M Grant from NHGRI to Automate the HLS-CATCH Targeted DNA Sample Preparation Method

BEVERLY, Mass. — May 21, 2019— Sage Science, a developer of products for improving sample preparation processes in life science applications, today announced the award of $1.8M from the National Human Genome Research Institute. The grant funds a two-year program … more »

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Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids

Authors: Candice P. Chu, Mary B. Nabity Info: From the Department of Veterinary Pathobiology at Texas A&M, this study evaluates best practices for small RNA sequencing from canine biofluid samples (serum and urine). The study compares RNA-seq results after using … more »

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Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats

February 2019 Authors: Luısa Camacho, Camila S. Silva, Joseph P. Hanig, Robert P. Schleimer, Nysia I. George, John F. Bowyer Info: A report from the USDA and others evaluate the effect of amphetamine and methamphetamine toxicity on immune systems and … more »

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AGBT 2019 Re-Cap

AGBT 2019 was a smashing success this year. Featuring a triumphant return to Marco Island FL with postcard perfect weather, the science was (as usual) top-notch. The renovated Marriott greatly upgraded its conference facilities and added an attractive new tower … more »

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Linked-Read Sequencing Advances Understanding of Cancers

A new study* from the University of Connecticut Medical School, Jackson Labs, and collaborators demonstrate the utility of using emulsion based linked-read sequencing (10X Genomics) for cancer research. Published in January’s Otology & Neurotology studies patients with Neurofibromatosis Type 2 … more »

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SageELF Size Selection for PacBio Circular Consensus Sequencing

A new preprint has landed on BioRxiv that reports on high-accuracy circular consensus sequencing (CCS) on the PacBio Sequel. The study, “Highly-accurate long-read sequencing improves variant detection and assembly of a human genome”, is authored by PacBio and an impressive … more »

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Enhanced detection of circulating tumor DNA by fragment size analysis

November 2018 Authors: Florent Mouliere et al. Info: This study from Cancer Research UK and a large team of collaborators is a continuation of work evaluating circulating tumor DNA (ctDNA) and the significance of sub-167 base pair cell-free DNA as … more »

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Small-seq for single-cell small-RNA sequencing

September 2018 Authors: Michael Hagemann-Jensen, Ilgar Abdullayev, Rickard Sandberg and Omid R Faridani Info: A new protocol from researchers at the Karolinska Institutet and the Ludwig Institute for Cancer Research outline a method for making small RNA sequencing libraries from … more »

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