Tag Archives: microRNA

Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit

March 2018 Authors: Jonas Hönig, Ivana Mižíková, Claudio Nardiello, David Emanuel Surate Solaligue, et al. Info: In Germany, researchers delivered microRNA inhibitors to pregnant mice, finding that the antimiRs were then detectable in offspring, where they caused fewer off-target effects … more »

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Study protocol: rationale and design of the community-based prospective cohort study of kidney function and diabetes in rural New Mexico, the COMPASS study

February 2018 Authors: Antonin Jaros, Hafiz Sroya, Venita Wolfe, Vikas Ghai, et al. Info: Scientists report design and launch of the COMPASS study, a prospective, longitudinal cohort in rural New Mexico aimed at better understanding diabetic chronic kidney disease and … more »

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Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI

December 2017 Authors: Ruben Boers, Joachim Boers, Bas de Hoon, Christel Kockx, et al. Info: Scientists at Erasmus Medical Center determined that analysis of genome-wide methylation is challenging when fragment sizes are too small and that better epigenetic results are … more »

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Micro RNA’s (miRNA’s) may help explain expression of multiple genes in Alzheimer’s Frontal Cortex

September 2017 Authors: James Bennett and Paula Keeney Info: Scientists from Neurodegeneration Therapeutics used RNA-seq to compare microRNAs found in Alzheimer’s brain samples and controls. They identified 55 up-regulated genes and 191 down-regulated genes in the Alzheimer’s samples. PippinHT was … more »

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Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

July 2017 Authors: Justin Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John Hoidal, and Namakkal Rajasekaran Info: Scientists from the University of Alabama at Birmingham and other institutions studied a gene previously associated with oxidative stress, analyzing differential expression in … more »

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Co-chaperone Hsp70/Hsp90 organizing protein (Hop) is Required for Transposon Silencing and piRNA Biogenesis

February 2017 Authors: Joseph A. Karam, Rasesh Y. Parikh, Dhananjaya Nayak, David Rosenkranz and Vamsi K. Gangaraju Info: Scientists from South Carolina and Mainz, Germany, studied Hop, a co-chaperone that interacts with a piRNA in Drosophila. They found that knocking … more »

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Comprehensive evaluation of extracellular small RNA isolation methods from serum in high throughput sequencing

January 2017 Authors: Yan Guo, Kasey Vickers, Yanhua Xiong, Shilin Zhao, Quanhu Sheng, Pan Zhang, Wanding Zhou and Charles R. Flynn Info: Scientists from Vanderbilt University and Van Andel Research Institute compared methods for isolating circulating extracellular small non-coding RNAs. … more »

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The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

December 2016 Authors: Samer G. Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, et al. Info: Researchers from the HudsonAlpha Institute, the University of Florida, and other institutions studied the role of rigidity in the extracellular matrix, finding that … more »

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Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples

November 2016 Authors: Alan Van Goethem, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, et al. Info: Scientists at Ghent University and Baylor College of Medicine evaluated protocols for depleting abundant RNAs from blood and serum samples to improve the ability to … more »

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Association of MicroRNAs with Antibody Response to Mycoplasma bovis in Beef Cattle

August 2016 Authors: Eduardo Casas, Guohong Cai, Larry A. Kuehn, Karen B. Register, Tara G. McDaneld, John D. Neill Info: USDA scientists performed a longitudinal study of young cows to identify microRNAs linked to a serum antibody produced after exposure … more »

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