Monthly Archives: October 2013

Ion World and ASHG: What a Week!

Between Ion World and ASHG, last week was a conference frenzy here in Boston. The Sage Science team had a great experience at both events — it was wonderful getting to talk to so many scientists in the sequencing field, … more »

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Semiconductor-based DNA sequencing of histone modification states

October 2013 Authors: Christine S. Cheng, Kunal Rai, Manuel Garber, Andrew Hollinger, Dana Robbins, Scott Anderson, Alyssa Macbeth, Austin Tzou, Mauricio O. Carneiro, Raktima Raychowdhury, Carsten Russ, Nir Hacohen, Jeffrey E. Gershenwald, Niall Lennon, Chad Nusbaum, Lynda Chin, Aviv Regev … more »

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Welcome to Beantown, ASHG Attendees

The annual meeting of the American Society of Human Genetics will be taking place a hop, skip, and a jump from our office — and we can’t wait! It’s one of the biggest genetics meetings on the calendar, and this … more »

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Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients

October 2013 Authors: David W. Collins, Harini V. Gudiseva, Benjamin T. Trachtman, Matthew Jerrehian, Thomasine Gorry, William T. Merritt III, Allison L. Rhodes, Prithvi S. Sankar, Meredith Regina, Eydie Miller-Ellis, Joan M. O’Brien Info: Researchers at the University of Pennsylvania … more »

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Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

October 2013 Authors: Michelle Schorn, Judith Zettler, Joseph P. Noel, Pieter C. Dorrestein, Bradley S. Moore, and Leonard Kaysser Info: Scientists from California and Germany teamed up to study genes that encode for the biosynthesis of an important component of … more »

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Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

October 2013 Authors: Michelle Schorn, Judith Zettler, Joseph P. Noel, Pieter C. Dorrestein, Bradley S. Moore, and Leonard Kaysser Info: Collaborators in the U.S. and Germany report on the genetic pathway for the production of epoxyketone proteasome inhibitors, used as … more »

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Quick, sensitive and specific detection and evaluation of quantification of minor variants by high-throughput sequencing

October 2013 Authors: Ross Ka-Kit Leung, Zhi Qiang Dong, Fei Sa, Cheong Meng Chong, Si Wan Lei,c Stephen Kwok-Wing Tsui and Simon Ming-Yuen Lee Info: Scientists from the University of Hong Kong and the University of Macau, China, evaluate errors … more »

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Genomic architecture of ecologically divergent body shape in a pair of sympatric crater lake cichlid fishes

October 2013 Authors: PAOLO FRANCHINI, CARMELO FRUCIANO, MARIA L. SPREITZER, JULIA C. JONES, KATHRYN R. ELMER, FREDERICO HENNING and AXEL MEYER Info: Researchers at the University of Konstanz, Germany, look at the speciation of chichlid fishes using the ddRAD technique. … more »

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Improved Protocols for Illumina Sequencing

October 2013 Authors: Iraad F. Bronner, Michael A. Quail, Daniel J. Turner, and Harold Swerdlow Info: A comprehensive overview of the state-of-the state of Illumina sequencing, from the Wellcome Trust Sanger Institute and Oxford Nanopore Technologies. The value of narrow … more »

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