Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

October 2013

Authors:
Michelle Schorn, Judith Zettler, Joseph P. Noel, Pieter C. Dorrestein, Bradley S. Moore, and Leonard Kaysser

Info:
Collaborators in the U.S. and Germany report on the genetic pathway for the production of epoxyketone proteasome inhibitors, used as anti-cancer therapeutic agents, in bacterial strains. The Pippin Prep was used to size select DNA prior to Ion Torrent sequencing.

Citation:
ACS Chem. Biol. 2014, 9, 301−309

doi:10.1021/cb400699p

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